Ongoing Developments in Biologic Therapy



Summary

Mechanism of Action of IL-12/23–Targeted Therapies

Role of Th17 Responses

Agents in Development

Future Directions

Conclusion

References

Ongoing Developments in Biologic Therapy


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Expert Practice: New Biologic Agents in Development for Psoriasis
New Biologic Agents in Development for Psoriasis

Release date: February 2008
Expiration date: February 28, 2009

Estimated time to complete activity: 30 minutes

Sponsored by Curatio CME Institute LLC

Support for this activity has been provided through an educational grant from Genentech, Inc.

Activity Overview
There is considerable excitement surrounding several new biologic agents with novel mechanisms of action and their potential as treatments for psoriasis. We recently interviewed Gerald G. Krueger, MD, Professor of Dermatology at the University of Utah in Salt Lake City, to gain his insights on the emerging data for these agents. In this Expert Practice, Dr. Krueger discusses the mechanisms of action of these similar agents in development, as well as the clinical data reported to date.

Target Audience
This activity has been designed to meet the educational needs of physicians and other health care professionals involved in the care of patients with psoriasis.

Learning Objectives
Upon completion of this activity, participants should be able to:
  • Describe the mechanisms of action of new biologic agents in development
  • Discuss clinical studies investigating biologic agents that target interleukin-12 and interleukin-23
  • Compare the safety and efficacy of new agents in development
Faculty
Gerald G. Krueger, MD
Professor of Dermatology
Department of Dermatology
University of Utah
Salt Lake City, Utah

Accreditation Statement
Curatio CME Institute is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

Credit Designation
Curatio CME Institute designates this educational activity for a maximum of 0.5 AMA PRA Category 1 CreditTM. Physicians should only claim credit commensurate with the extent of their participation in the activity.

Method of Participation
There are no fees for participating in this CME activity. To receive credit during the period February 2008 to February 28, 2009, participants must (1) read the learning objectives and disclosure statements, (2) study the educational activity, (3) complete the posttest, and (4) complete the activity evaluation form, including the certificate information section.

Media
The Internet was selected as the instructional format to accommodate the learning preferences of a significant portion of the target audience.

Disclosure
In accordance with the ACCME’s Standards for Commercial Support, all CME providers are required to disclose to the activity audience the relevant financial relationships of everyone in a position to control content of an educational activity. A relevant financial relationship is a relationship in any amount occurring in the last 12 months with a commercial interest whose products or services are discussed in the CME activity content over which the individual has control. Relationship information appears below:

Gerald G. Krueger, MD, has disclosed the following relevant financial relationship(s):

Consultant/Advisory Board: Abbott, Almirall, Alza, Amgen, Astellas, Boehringer Ingelheim, Barrier Therapeutics, Bristol-Myers Squibb, Centocor, Connetics, Genentech, MedaCorp, Medicis, Warner Chilcott
Research: Abbott, Amgen, Centocor
Speaker: Abbott, Amgen, Boehringer Ingelheim, Centocor, Connetics, Warner Chilcott
Stockholder: Zars

Dr. Krueger discusses the unlabeled or investigational use of a commercial product.

Curatio CME Institute

Shari J. Dermer, PhD, Medical Director, has disclosed no relevant financial relationships.

Thomas F. Finnegan, PhD, Medical Writer, has disclosed no relevant financial relationships.

Brett Mutschler, CME Director, has disclosed no relevant financial relationships.

Lauren Showers, Program Coordinator, has disclosed no relevant financial relationships.

Jonathan S. Simmons, ELS, Managing Editor, has disclosed no relevant financial relationships.

Disclaimer
The information presented in this activity is for continuing medical education purposes only and is not meant to substitute for the independent medical judgment of a physician regarding diagnosis and treatment of a specific patient’s medical condition.

Unapproved Product Use
This educational activity may contain discussion of published and/or investigational uses of agents that are not indicated by the US Food and Drug Administration. Curatio CME Institute and Genentech, Inc. do not recommend the use of any agent outside the labeled indications.

The opinions expressed in this educational activity are those of the faculty and do not necessarily represent the views of Curatio CME Institute or Genentech, Inc. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications, and warnings.

Hardware/Software Requirements
  • Version 5.0 or higher for Microsoft Internet Explorer or Netscape 6 or higher
  • If you are using a Mac computer system and are experiencing problems with your browser, we suggest downloading the latest version of Firefox for Mac
Contact Information
PsoriasisTx
100 Campbell Boulevard
Suite 103
Exton, PA 19341
editor@psoriasistx.com

Policy on Privacy and Confidentiality
Curatio CME Institute makes every effort to protect the privacy of PsoriasisTx users; user information is used only to maintain records as required by the American Medical Association (AMA) and the ACCME.

Curatio CME Institute does not require individuals to register to use PsoriasisTx; registration is only required for physicians, health care professionals, and other users to participate in and receive CME/CE credit for accredited educational programs hosted on PsoriasisTx.

Curatio CME Institute is required by the AMA and the ACCME (and occasionally by other accrediting organizations) to collect user information that will allow Curatio CME Institute to issue a CME/CE certificate. Curatio CME Institute is required to keep this information on file for up to 6 years. The information is stored in a secure database and used only to verify individual participation in a CME/CE activity and to reissue a certificate if a user’s original certificate is lost or misplaced.

Information gathered through PsoriasisTx will not be released to any other company or organization for any purpose; this information remains confidential. At the end of the mandatory 6-year period, these records will be destroyed.

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If you have any questions about PsoriasisTx or any Curatio CME Institute policies, you may contact us at editor@psoriasistx.com.

Thank you for using PsoriasisTx.




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