Release date: September 2008
Expiration date: September 30, 2009

Estimated time to complete activity: 45 minutes

Sponsored by Curatio CME Institute

Support for this activity has been provided through an educational grant from Genentech, Inc.

Activity Overview
A 45-year-old male patient with a 15-year history of recalcitrant psoriasis presents to your virtual office, and you—in consultation with Jeffrey M. Weinberg, MD, of St. Luke's-Roosevelt Hospital Center and Beth Israel Medical Center in New York—are providing his care. Among the issues that arise over the course of this case are the safety and efficacy of combination therapy with biologics (eg, etanercept, efalizumab) and traditional systemic therapy agents (eg, methotrexate), monitoring for such adverse events as thrombocytopenia and hemolytic anemia, and the management of transient mild breakthrough and generalized inflammatory flare. This activity follows the progression of this case over several months, solicits your clinical input on key aspects of the case, and presents treatment recommendations provided from other clinicians who have “consulted” on this case.

Target Audience
This activity has been designed to meet the educational needs of dermatologists, dermatology residents and fellows, and other health care professionals involved in the care of patients with psoriasis.

Learning Objectives
Upon completion of this activity, participants should be able to:

• Describe issues that result in difficult-to-treat cases
• Discuss treatment strategies, such as combination therapy and transitioning agents
• Evaluate how clinical data impacts daily dermatology practice

Faculty
Jeffrey M. Weinberg, MD
Department of Dermatology
St. Luke's-Roosevelt Hospital Center
Beth Israel Medical Center
New York, New York

Accreditation Statement
Curatio CME Institute is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

Credit Designation
Curatio CME Institute designates this educational activity for a maximum of 0.75 AMA PRA Category 1 Credit™. Physicians should only claim credit commensurate with the extent of their participation in the activity.

Method of Participation
There are no fees for participating in this CME activity. To receive credit during the period September 2008 to September 30, 2009, participants must (1) read the learning objectives and disclosure statements, (2) study the educational activity, (3) complete the posttest, and (4) complete the activity evaluation form, including the certificate information section.

Media
The Internet was selected as the instructional format to accommodate the learning preferences of a significant portion of the target audience.

Disclosure
In accordance with the ACCME’s Standards for Commercial Support, all CME providers are required to disclose to the activity audience the relevant financial relationships of everyone in a position to control content of an educational activity. A relevant financial relationship is a relationship in any amount occurring in the last 12 months with a commercial interest whose products or services are discussed in the CME activity content over which the individual has control. Relationship information appears below:

Jeffrey M. Weinberg, MD has disclosed the following relevant financial relationships:

Speaker	Abbott, Amgen, Genentech

Curatio CME Institute

Disclaimer
The information presented in this activity is for continuing medical education purposes only and is not meant to substitute for the independent medical judgment of a physician regarding diagnosis and treatment of a specific patient’s medical condition.

Unapproved Product Use
This educational activity may contain discussion of published and/or investigational uses of agents that are not indicated by the US Food and Drug Administration. Curatio CME Institute and Genentech, Inc. do not recommend the use of any agent outside the labeled indications.

The opinions expressed in this educational activity are those of the faculty and do not necessarily represent the views of Curatio CME Institute and Genentech, Inc. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications, and warnings.

Hardware/Software Requirements

• Version 5.0 or higher for Microsoft Internet Explorer or Netscape 6 or higher
• If you are using a Mac computer system and are experiencing problems with your browser, we suggest downloading the latest version of Firefox for Mac
• Javascript-enabled browser
• High-speed Internet connection
• Adobe Flash Player plugin v.8.0+

Contact Information
PsoriasisTx.com
100 Campbell Boulevard
Suite 103
Exton, PA 19341
editor@curatiocme.com

Policy on Privacy and Confidentiality
Curatio CME Institute makes every effort to protect the privacy of PsoriasisTx.com users; user information is used only to maintain records as required by the American Medical Association (AMA) and the ACCME.

Curatio CME Institute does not require individuals to register to use PsoriasisTx.com; registration is only required for physicians, health care professionals, and other users to participate in and receive CME/CE credit for accredited educational programs hosted on PsoriasisTx.com.

Curatio CME Institute is required by the AMA and the ACCME (and occasionally by other accrediting organizations) to collect user information that will allow Curatio CME Institute to issue a CME/CE certificate. Curatio CME Institute is required to keep this information on file for up to 6 years. The information is stored in a secure database and used only to verify individual participation in a CME/CE activity and to reissue a certificate if a user’s original certificate is lost or misplaced.

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Thank you for using PsoriasisTx.com.

Begin CME Activity