Registration benefits include: Access to CME/CE programs and certification Free subscription to Biologic Bulletin newsletter Reminders of new CME/CE activities REGISTER NOW Ask the Expert : Search Results Search Results This section of PsoriasisTx.com contains our Ask the Expert archive, where users can review the challenging clinical questions that have addressed by our expert panel regarding all aspects of psoriasis treatment, including therapies for chronic plaque psoriasis. Here, health care professionals can peruse pertinent questions posted by their colleagues (and, in some cases, patients) on topics ranging from psoriatic arthritis treatment to treating patients with comorbidities such as cancer or hepatitis. All questions have answers (often with accompanying commentary) provided by our panel of medical experts and include evidence-based recommendations where applicable. These archives are an excellent research tool for clinicians involved in the treatment of psoriasis and its comorbidities. The information contained in this section is comprehensive and provides a valuable, real-world resource for dermatology professionals. As you scroll through this section, notice that the results are arranged in categories: Efficacy, Side Effects/Safety, Dosing & Administration, and Treatment Considerations. These groupings facilitate navigation to the topics you wish to research. 23 question(s) listed Mechanism of Action CME - Biologic psoriasis treatment and cardiovascular risk reduction For biologic agents used to treat severe psoriasis, what are the underlying mechanisms of action that reduce cardiovascular risks?    Click Here To Read Answer CME - Animal models of psoriasis Are there any good animal models to test new drugs for psoriasis?    Click Here To Read Answer CME - Deficiency of p40 and its role in psoriasis and immune response Centocor has identified a cohort of patients who are deficient in p40. They have increased bacterial infections, no increased viral infections, and no cases of psoriasis. The gene(s) that code for p40...    Click Here To Read Answer Clinical Trials Concurrent administration of cyclosporine and etanercept? What is your experience giving cyclosporine together with etanercept?    Click Here To Read Answer Side Effects/Safety CME - Use of infliximab in a patient who will receive a silicone breast implant I have a 36-year-old patient with psoriasis who has been receiving infliximab every 8 weeks for 2 years. Her psoriasis cleared after the induction phase. She intends to undergo an abdominal lipoaspira...    Click Here To Read Answer CME - Tuberculosis testing, vaccinations, and the American Academy of Dermatology and National Psoriasis Foundation recommendations What are the recommendations for patients who were tested for tuberculosis prior to onset of biologic therapy but did not receive all the immunizations listed in the current American Academy of Dermat...    Click Here To Read Answer CME - Methotrexate and pregnancy What are the recommendations regarding treatment with methotrexate and pregnancy in a female patient?    Click Here To Read Answer CME - Peripheral edema and adalimumab A patient developed marked peripheral edema after the first dose of adalimumab. Is this a recognised adverse reaction and what are the mechanisms involved?    Click Here To Read Answer CME - PPD testing in patients on anti-TNF agents What is the recommended protocol for tuberculosis testing in patients who will be placed on an anti–tumor necrosis factor (TNF) agent?    Click Here To Read Answer Biologic treatment, male patients, and pregnancy Are there any concerns about placing a male patient who is trying to father a child on a biologic such as efalizumab?    Click Here To Read Answer Weight gain in patients receiving anti–tumor necrosis factor agents? Most of our patients on anti–tumor necrosis factor (TNF) drugs for psoriasis have put on a lot of weight since treatment was commenced. Is TNF-alpha normally associated with a mechanism for weight con...    Click Here To Read Answer Biologics and reactivation of latent tuberculosis What are your thoughts on biologics and their role in reactivation of latent tuberculosis? Is etanercept, because of its mechanism of action, less likely to reactivate tuberculosis? How often should y...    Click Here To Read Answer Treatment Considerations CME - Treatment options for palmar psoriasis What is the recommended treatment for severe disabling palmar psoriasis (differential diagnosis includes hand eczema) in a patient with coronary artery disease, obesity, and recent placement of a defi...    Click Here To Read Answer CME - Possible effects of gastric bypass surgery on psoriasis in an obese patient What recommendations do you have for the treatment of an obese patient with psoriasis and psoriatic arthritis who is considering gastric bypass surgery? Will it improve the psoriatic disease? Are ther...    Click Here To Read Answer CME - Treatment of a patient with long-standing psoriasis that is unresponsive to acitretin I have a 50-year-old patient who has had psoriasis since he was 30. Two months ago he developed erythroderma and was treated with acitretin 25 mg daily for 1 month. His erythroderma cleared, so the ac...    Click Here To Read Answer CME - Calculating Nail Psoriasis Severity Index (NAPSI) How can I calculate Nail Psoriasis Severity Index (NAPSI)?    Click Here To Read Answer CME - Biologic treatment of adolescents Are there any biologic agents that can be used in an adolescent (12-year-old) patient with severe psoriasis that is not responding to topical treatments or phototherapy?    Click Here To Read Answer CME - Biologics and tuberculosis A patient who has been on infliximab for 14 months had a positive PPD. I discontinued the infliximab. Is there a biologic agent that I can safely use in this patient?    Click Here To Read Answer Etanercept and breast cancer I have a patient who had been on etanercept 50 mg for the past 4 years with good control of her psoriasis. She was recently diagnosed with ductal carcinoma in situ (DCIS) breast cancer and no lymph no...    Click Here To Read Answer Efalizumab treatment in a patient receiving peginterferon and ribavirin for hepatitis C Do you think it's safe to treat somebody for psoriasis with efalizumab at the same time as they are being treated for hepatitis C with peginterferon and ribavirin for 48 weeks? I cared for a patient w...    Click Here To Read Answer Treatment options for a patient with plaque psoriasis and a history of hepatitis C and throat cancer Do you have any treatment suggestions for a 67-year-old male who has severe plaque psoriasis, a history of hepatitis C, and laryngectomy for throat cancer 5 years ago, and who previously did not respo...    Click Here To Read Answer Biologic treatment in patients with successfully treated skin cancer I recently had a squamous cell carcinoma that was caused by too many PUVA treatments removed. Is there a biologic that would be safe for my very severe psoriasis, even though I have had skin cancer? I...    Click Here To Read Answer Pregnancy and the use of biologics A 32-year-old female patient who has had chronic moderate psoriasis since age 22 had success with etanercept for the past 18 months. She is now trying to get pregnant, but she is concerned about remai...    Click Here To Read Answer   Ask the Expert Home